PHARMACEUTICAL SCIENCES (PHSC)

L.D. Milne, Dean, College of Pharmacy, 4301 West Markham, Little Rock, AR 72205, 686-5557

PROFESSORS BRADLEY, LATTIN, LIGHT, McKAY, MILNE, MORRISON, NELSON, SORENSON; PROFESSORS EMERITI BRECKINRIDGE, JORDIN, McCOWAN; ASSOCIATE PROFESSORS BREEN, COMPADRE (C.), EPPERSON, FIFER, KEARNS, KELLEY, KNOLL, McCORMACK, PYNES, UNDERWOOD; ASSISTANT PROFESSORS BERG, COMPADRE (L.), GURLEY, VANDERGRIFT, WOLFE; ADJUNCT ASSISTANT PROFESSORS AUSTIN, MARTINKA, SNELLINGS, SWINDLE, YOUNG; ADJUNCT INSTRUCTOR McGUIRE

Degree Conferred: M.S. (PHSC)

Areas of Concentration: hospital pharmacy, nuclear pharmacy, medicinal chemistry, pharmaceutics, pharmacognosy, pharmacology, and radiological health. Advanced study may also be pursued jointly in the Department of Pharmacology and in Pharmaceutical Sciences.

Prerequisites to Degree Program: Each applicant must comply with the general requirements for admission to the Graduate School of the University of Arkansas for Medical Sciences. In addition, applicants for advanced studies in the areas of hospital pharmacy, nuclear pharmacy, and pharmaceutics must possess a Bachelor of Science or Pharm.D. degree in pharmacy from an accredited American college or university, or from a foreign university whose requirements are comparable to those of accredited American colleges or universities. Applicants for advanced studies in medicinal chemistry, pharmacognosy, pharmacology, or radiological health must possess an undergraduate/professional degree in pharmacy or a bachelor's degree in the physical or biological sciences, the health sciences, or in allied fields from an accredited American college or university, or from a foreign university whose requirements are comparable to those of accredited American colleges or universities.

The Graduate Studies Committee of the College of Pharmacy will review each application to determine the eligibility of the applicant for the identified areas of study in the pharmaceutical sciences. Each program is developed on the basis of the student's background and objectives. The undergraduate program of a student applicant should comprise sufficient basic courses in physical and biological, pharmaceutical, and/or allied sciences to enable the student to pursue graduate work successfully in the indicated area of concentration. If the Committee should decide a student is not sufficiently prepared, additional undergraduate or graduate instruction may be required but will not be credited toward the advanced degree.

The major field of study may be selected from one of the approved areas of the pharmaceutical sciences for the advanced degree. Courses in the minor field of study may be selected from one of the approved areas of the pharmaceutical sciences or from the supporting departments of the University.

Requirements for the Master of Science Degree: A minimum of 30 semester hours of graduate study is required for the master's degree. Of this amount, 24 semester hours are given to didactic instruction and six hours are given to thesis. The 24 semester hours of didactic instruction consists of a minimum of 12 hours in the major field of study.

Completion of an approved one-year residency in hospital pharmacy or equivalent experience (five years) as a hospital pharmacist will be required, in addition to the above academic courses, as a corequisite for the M.S. degree with a major emphasis in hospital pharmacy.

Courses: Pharmaceutical Sciences (PHSC)

501V Radiation Biology (2-4) Lecture and laboratory studies of the effects of ionizing radiation on living systems. Hours and credit to be arranged.

502V Advanced Pharmaceutical Chemistry: Synthetic and Natural Products (3-6) (On demand) Precursors, reactions, methods of production, classification, properties, uses and structure-activity correlation of synthetic and natural compounds used as therapeutic agents.

5041 Pharmaceutical Science Seminar (On demand) Members of faculty and graduate students meet regularly for discussion and current studies in the field of the pharmaceutical sciences.

508V Pharmacy Administration (2-6) (On demand) Discussion of the development, function, responsibilities, organization and administration of the hospital and the hospital pharmacy. Presented from the viewpoints of the administrative responsibilities of the hospital pharmacist.

511V Health Physics (2-4) Protection of people and the environment from the harmful effects of ionizing radiation. Prerequisite: PHSC 5191, 5182 or equivalent.

5121 Health Physics Laboratory Laboratory and field applications of health physics practice including surveying, hazards, evaluation, ecological considerations, and other problems related to the use of x-rays, radioisotopes and nuclear reactors. Prerequisite or corequisite: PHSC 511V, and consent of instructor.

5133 Current Topics in Medicinal Chemistry Selected topics of current interest and investigation in medicinal chemistry are discussed, including the molecular basis of drug action, new trends in drug design, and the biochemical basis for the development of new classes of drugs.

5135 Protecting Group Chemistry (For Biological Scientists) Review of the commonly used chemical methods for derivatizing peptides and other organic intermediates with protecting groups. Emphasis will be placed upon advantages of various protecting groups for reversible functional group derivatization, stability of derivatives to reaction conditions, and methods of removal. Prerequisites: graduate standing and consent of instructor.

5162 Scientific Literature Retrieval Survey of scientific literature, particularly of the biological and chemical sciences, and the use of general and specific index and abstract tools in science, including search strategy and new computer-based retrieval programs. Credit, 2 hours. Two lectures per week. Prerequisite: consent of instructor.

517V Advanced Biopharmaceutics and Pharma-cokinetics (2-3) Quantitative treatment of the dynamics of drug absorption, distribution and excretion including the development of mathematical models for these processes and their practical application in clinical practice. Credit: 2-3 hours on demand. Prerequisites: graduate standing and consent of instructor.

5182 Radioisotope Tracer Technology Theory and technology concerning the applications of radioisotopes to research and industry. Radiological health and safety aspects are emphasized. Prerequisite: consent of instructor.

5191 Radioisotope Laboratory Techniques required for the application of radioisotopes to research and industry. Radiological health and safety procedures are emphasized. Credit, one hour. Prerequisite or corequisite: PHSC 5182.

5192 Pharmacokinetic Research Design and Data Analysis Review of current methods used in the design of pharmacokinetic investigations in animals and man, and of techniques used for analysis of pharmacokinetic data. Emphasis placed on advantages of various mathematical techniques for pharmacokinetic data analysis, the ethics and logistics of pharmacokinetic study design and methods used to present pharmacokinetic data. Prerequisite: graduate standing and consent of instructor, and PHSC 517V or PCOL 502V.

5223 Public Health Administration, Vital Statistics, and Practice Topics in those fields of the medical and related sciences which form the foundation of public health work. Included are discussions of communicable disease, nutrition, water and air pollution, waste and sewage disposal, and vital statistics. Lecture 3 hours per week.

5231 Advanced Nuclear Instrumentation Laboratory introduction to advanced nuclear instrumentation including radioactivity measurements using liquid scintillation counters, the recording spectrometer, and vacuum tube as well as solid-state multichannel analyzers. Stresses the utilization and maintenance of multichannel analyzers. Energies, half-lives, and absolute disintegration rates of alpha, beta and gamma emitters will be determined by various methods. Simple and complex gamma ray spectra will be analyzed and resolved. Prerequisites: PHSC 5191 and 5182 and consent of instructor.

5243 The Theory and Technology of Sterile Solutions (or Products) Theory and techniques involved in the preparation of medicinals for parenteral therapy involving various dosages. Lecture 2 hours, laboratory 3 hours. Prerequisite: advanced standing and consent of the instructor.

5253 Toxicology Various poisons, their identification, mode of action, detection, isolation, detoxification, and quantitative evaluation of these inorganic and organic compounds. The routes of absorption, metabolism, and excretion of poisons. Recognition and treatment of poisoning; use and misuse, and antidotes. Lecture 2 hours, laboratory 3 hours per week. Prerequisites: PCOL 4124 and 4134.

526V Special Problems in the Pharmaceutical Sciences (1-4) Individual investigation, other than thesis of a special problem selected or assigned. Hours and credit to be arranged.

527V Research in Pharmaceutical Sciences (1-4) Hours and credit to be arranged. Prerequisites: graduate standing and consent.

5282 Advanced Nuclear Pharmacy (II) Applied physiology, pharmacological basis and standard procedures for contemporary radiopharmaceuticals. Administration of a nuclear pharmacy and methods of procurement, formulation, quality control, assay, and dispensing. The administered dose, trade names, generic names, use, manufacture, interactions and adjunct medication of radiopharmaceuticals in current major use and radiopharmaceutical quality control. Prerequisites: PHSC 5191, 5182, and consent of instructor.

5291 Advanced Nuclear Pharmacy Laboratory (II) Compounding of representative radiopharmaceuticals, including in-house kits and specially radiopharmaceuticals and their origin, preparation, compounding, quality control, and dispensing. The relation of individual radiopharmaceuticals in current major use and radiopharmaceutical quality control. Pre- or corequisite: PHSC 5282 and consent of instructor.

5303 Advanced Physical Pharmacy Physiochemical principles governing the development of drug dosage forms.

5323 Pharmacology of Chemotherapeutic Agents Antibiotics and anti-infectives. Metabolism, mechanism of action, selective toxicity, immunologic properties, and synergistic actions are emphasized.

5333 Applied Radiochemistry Theory and application of radionuclides in chemistry, biochemistry, medicine and related fields. Emphasis on applications in health-related sciences. Pre- or corequisites: PHSC 5182 and 5191.

5341 Applied Radiochemistry Laboratory A laboratory course designed to introduce and apply the techniques and theory introduced in applied radiochemistry lecture course (PHSC 5333). Pre- or corequisites: PHSC 5182, 5191, and 5333.

600V Master's Thesis (1-6) Prerequisites: graduate standing and consent.