 DR. WALTER BOTTJE Director of the Center of Excellence for Poultry Science and Department Head Physiologist |
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Dr. Bottje graduated with honors in 1976, receiving a B.S. degree in Zoology with a Chemistry minor from Eastern Illinois University. After receiving an M.S. from Southern Illinois University, he completed a Ph.D. at the University of Illinois prior to being hired at the University of Arkansas in 1985. Dr. Bottje developed a research program focused on antioxidants and toxicology with an NIH grant he received in 1987.
In 1995, Dr. Bottje became the Associate Director of
the Center of Excellence for Poultry Science (CEPS) with a 30% administrative
appointment. In June 2003, Dr. Bottje was named the Department Head and Director
of the Center of Excellence for Poultry Science.
Dr. Bottje's current research focus is on the role that mitochondria play in
the phenotypic expression of feed efficiency in broilers. This research
has been supported by grants from USDA-NRI and Cobb-Vantress, Inc. (Siloam Springs,
AR). Previous research emphasis was on the role of mitochondria in the
pathophysiology of ascites (pulmonary hypertension syndrome).
SIGNIFICANT PAPERS
Ojano-Dirain, C., M. Iqbal, D. Cawthon, S. Swonger, T. Wing, M. Cooper, and W. Bottje, 2004. Site-specific effects in electron transport in duodenal mtiochondria is associated with low feed efficiency in broiler breeder males. Poultry Sci. 83:1394-1403.
Ojano-Dirain, C., W. Bottje, T. Wing and M. Cooper, 2005. Glutathione and respiratory chain complex activities in duodenal mitochondria from broilers with low and high feed efficiency. Poultry Sci. 84:782-788.
Iqbal, M., Pumford, N., Lassiter, K., Tang, Z. X., Wing, T., M. Cooper, W. G. Bottje, 2005. Compromised Liver Mitochondrial Function and Complex Activity in Low Feed Efficient Broilers Within a Single Genetic Line Associated With Higher Oxidative Stress and Differential Protein Expression. Poult. Sci. 84:933-941.
Ojano-Dirain, C., N.R. Pumford, M. Iqbal, T. Wing, and M. Cooper, W. G. Bottje, 2005. Biochemical evaluation of mitochondrial respiratory chain in duodenum of low and high feed efficient broilers, 2005. Poult. Sci. 84: 1926-1934.
Bottje, W., N. Pumford, C. Ojano-Dirain, M. Iqbal, and K. Lassiter, 2006. Feed efficiency and Mitochondrial Function. Poult. Sci. 85:8-14.
Lassiter, K., M. Iqbal, N. R. Pumford, C. Ojano-Dirain, N. Tinsley, T. Wing, M. Cooper, and W. Bottje, 2006. Differential expression of mitochondrial and extra-mitochondrial proteins in lymphocytes of low and high feed efficient male broilers. Poultry Sci. 85:2251-2259.
Ojano-Dirain, C., N.B. Tinsley, T. Wing, M. Cooper, and W. Bottje, 2006. Membrane potential and hydrogen peroxide production in duodenal mitochondria in broilers chickens (Gallus gallus) with low and high feed efficiency. Comp. Biochem Physiol. 2007: (in press
Bottje W.B. , Z Tang, M Iqbal, D Cawthon, R Okimoto, T Wing,
M Cooper, 2002. Association of mitochondrial function with feed efficiency within
a single genetic line of male broilers. Poultry Sci. 81: 546-555.
Tang Z, M Iqbal, D Cawthon, and WG Bottje, 2002. Heart and muscle
mitochondrial dysfunction in pulmonary hypertension syndrome in broilers (Gallus
domesticus) Comp. Biochem. Physiol. 132:527-540.
Iqbal M, JD Freiburger, GF Erf, and WG Bottje, 2002. Immunohistochemical
Evidence of Cytochrome c Oxidase Subunit II Involvement in Pulmonary Hypertension
Syndrome (PHS) in Broilers. Poultry Sci. 81:1231-1235.
Cawthon D, M Iqbal, J Brand, R McNew, and WG Bottje, 2004. Investigation
of Proton Conductance in Liver Mitochondria of Broilers with Pulmonary Hypertension
Syndrome. Poultry Sci. 83: 259-265.
M. Iqbal, N. R. Pumford, Z. X. Tang, K. Lassiter, T. Wing, M. Cooper,
and W. Bottje, 2004. Low Feed Efficient Broilers Within a Single Genetic Line
Exhibit Higher Oxidative Stress and Protein Expression in Breast Muscle With
Lower Mitochondrial Complex Activity. Poultry Sci. 83: 474-484
Bottje, W.G., M. Iqbal, C. Ojano-Dirain, N. R. Pumford, and K. Lassiter,
2004. Role of mitochondria in the phenotypic expression of feed efficiency. J. Appl. Poultry Res. 13:94-105.
CONTACT INFORMATION
Dr. Walter Bottje
Director, Center of Excellence for Poultry Science
University of Arkansas
Fayetteville, AR 72701
Telephone: 479-575-3699
FAX: 479-575-3026
